STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AKJ65656.15,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (269 aa)    
Predicted Functional Partners:
fhs
Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.
  
 
 0.968
yitJ_1
Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase.
  
 
 0.943
yitJ_2
Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase.
  
 
 0.943
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.930
glyA2
Serine hydroxymethyltransferase 2.
  
 
 0.924
gcvT
Aminomethyltransferase.
  
 
 0.917
folD
Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.915
AKJ64093.1
Thymidylate synthase.
     
 0.910
thyX
Thymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
     
 0.904
metF
5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
     
  0.900
Your Current Organism:
Kiritimatiella glycovorans
NCBI taxonomy Id: 1307763
Other names: DSM 26986, JCM 19195, K. glycovorans, Kiritimatiella glycovorans Spring et al. 2017, Verrucomicrobia bacterium L21-Fru-AB, bacterium L21-Fru-AB, strain L21-Fru-AB
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.