STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EG19_05855Hypothetical protein; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (452 aa)    
Predicted Functional Partners:
dnaG
Hypothetical protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
 
 0.979
EG19_04650
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.928
EG19_05860
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the MlaE permease family.
       0.786
EG19_01185
Single-stranded DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.784
EG19_06605
Vitamin B12-dependent ribonucleotide reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
   
 
 0.731
topA
Hypothetical protein; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA sup [...]
 
  
 0.724
dnaX
Hypothetical protein; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
 
 
 
 0.713
EG19_10775
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 
 0.702
EG19_05875
Hypothetical protein; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
     
 0.681
EG19_05865
ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
      0.632
Your Current Organism:
Thermoanaerobaculum aquaticum
NCBI taxonomy Id: 1312852
Other names: DSM 24856, JCM 18256, T. aquaticum, Thermoanaerobaculum aquaticum Losey et al. 2013, bacterium MP-01, strain MP-01
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