node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CALK_0543 | CALK_0544 | CALK_0543 | CALK_0544 | Glycoside hydrolase, GH9 family. | NAD(P) transhydrogenase subunit alpha part 1. | 0.453 |
CALK_0543 | CALK_0545 | CALK_0543 | CALK_0545 | Glycoside hydrolase, GH9 family. | NAD(P) transhydrogenase subunit alpha part 2. | 0.445 |
CALK_0543 | CALK_0546 | CALK_0543 | CALK_0546 | Glycoside hydrolase, GH9 family. | NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.445 |
CALK_0544 | CALK_0543 | CALK_0544 | CALK_0543 | NAD(P) transhydrogenase subunit alpha part 1. | Glycoside hydrolase, GH9 family. | 0.453 |
CALK_0544 | CALK_0545 | CALK_0544 | CALK_0545 | NAD(P) transhydrogenase subunit alpha part 1. | NAD(P) transhydrogenase subunit alpha part 2. | 0.994 |
CALK_0544 | CALK_0546 | CALK_0544 | CALK_0546 | NAD(P) transhydrogenase subunit alpha part 1. | NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.999 |
CALK_0544 | CALK_1221 | CALK_0544 | CALK_1221 | NAD(P) transhydrogenase subunit alpha part 1. | Malic enzyme; Belongs to the malic enzymes family. | 0.573 |
CALK_0544 | ilvC | CALK_0544 | CALK_0167 | NAD(P) transhydrogenase subunit alpha part 1. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.469 |
CALK_0544 | nadD | CALK_0544 | CALK_0093 | NAD(P) transhydrogenase subunit alpha part 1. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.490 |
CALK_0544 | nadE | CALK_0544 | CALK_1643 | NAD(P) transhydrogenase subunit alpha part 1. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.704 |
CALK_0544 | nadK | CALK_0544 | CALK_1671 | NAD(P) transhydrogenase subunit alpha part 1. | NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.539 |
CALK_0544 | rpoC | CALK_0544 | CALK_2098 | NAD(P) transhydrogenase subunit alpha part 1. | DNA-directed RNA polymerase, subunit beta-prime; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.557 |
CALK_0544 | tpx | CALK_0544 | CALK_0547 | NAD(P) transhydrogenase subunit alpha part 1. | Thiol peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily. | 0.443 |
CALK_0545 | CALK_0543 | CALK_0545 | CALK_0543 | NAD(P) transhydrogenase subunit alpha part 2. | Glycoside hydrolase, GH9 family. | 0.445 |
CALK_0545 | CALK_0544 | CALK_0545 | CALK_0544 | NAD(P) transhydrogenase subunit alpha part 2. | NAD(P) transhydrogenase subunit alpha part 1. | 0.994 |
CALK_0545 | CALK_0546 | CALK_0545 | CALK_0546 | NAD(P) transhydrogenase subunit alpha part 2. | NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.999 |
CALK_0545 | CALK_1221 | CALK_0545 | CALK_1221 | NAD(P) transhydrogenase subunit alpha part 2. | Malic enzyme; Belongs to the malic enzymes family. | 0.573 |
CALK_0545 | ilvC | CALK_0545 | CALK_0167 | NAD(P) transhydrogenase subunit alpha part 2. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.469 |
CALK_0545 | nadD | CALK_0545 | CALK_0093 | NAD(P) transhydrogenase subunit alpha part 2. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.490 |
CALK_0545 | nadE | CALK_0545 | CALK_1643 | NAD(P) transhydrogenase subunit alpha part 2. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.704 |