STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CALK_1388Stationary-phase survival protein SurE. (205 aa)    
Predicted Functional Partners:
CALK_1824
IMP dehydrogenase/GMP reductase.
    
 0.927
CALK_1047
GMP synthase.
    
 0.863
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 
     0.831
CALK_1078
NADH pyrophosphatase, Nudix hydrolase superfamily.
   
 
  0.821
CALK_1774
Competence/damage-inducible protein CinA; Belongs to the CinA family.
    
  0.744
pyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
  
  
 0.739
CALK_0266
Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
    
 0.730
CALK_1407
Signal transduction protein with CBS domain.
   
  0.728
CALK_0238
Purine nucleoside phosphorylase.
    
  0.726
CALK_1933
GAF domain/GGDEF domain-containing protein.
    
  0.721
Your Current Organism:
Chitinivibrio alkaliphilus
NCBI taxonomy Id: 1313304
Other names: C. alkaliphilus ACht1, Chitinivibrio alkaliphilus ACht1, candidate division TG3 bacterium ACht1, haloalkaliphilic bacterium ACht1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.