Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-occurrence
Co-expression
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[Homology]
Score
polADNA polymerase I; Derived by automated computational analysis using gene prediction method: Protein Homology. (880 aa)    
Predicted Functional Partners:
dnaN
DNA polymerase III subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.996
recA
Recombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.983
mutS
DNA mismatch repair protein MutS; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.966
DinG
ATP-dependent DNA helicase; Unwinds DNA; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.963
mutL
DNA mismatch repair protein MutL; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.956
Snf
RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.954
xth
Exodeoxyribonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.917
AKZ50356.1
Ribonuclease HII; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.901
topA
DNA topoisomerase I; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.899
dnaG
DNA primase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.896
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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