Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
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[Homology]
Score
manNPTS system mannose family transporter subunit IID; Hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology. (303 aa)    
Predicted Functional Partners:
manO
ManO; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.999
ManM
PTS mannose transporter subunit IIC; Derived by automated computational analysis using gene prediction method: Protein Homology.
 0.999
manX
PTS system mannost-specific transporter subunits IIAB; Phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.999
agaC_2
PTS mannnose transporter subunit IIC; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.992
AKZ50264.1
PTS mannnose transporter subunit IIA; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.955
AKZ50900.1
PTS system N-acetylgalactosamine-specific transporter subunit IIC; Catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake;involved in N-acetylgalactosamine transport; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.951
ptsH
Phosphocarrier protein HPr; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.934
AKZ50897.1
PTS N-acetylgalactosamine transporter subunit IIA; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.933
manA
Mannose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the mannose-6-phosphate isomerase type 1 family.
 
  
  0.923
PtsD
PTS mannnose transporter subunit IID; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 
0.919
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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