STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NadENicotinate phosphoribosyltransferase; Catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (486 aa)    
Predicted Functional Partners:
NadC
Nicotinate-nucleotide pyrophosphorylase; Catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.990
nadD
Nicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
 
 0.954
CinA
Damage-inducible protein CinA; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.950
PunA
Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
    
 0.917
deoD
Purine nucleoside phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.913
AKZ50173.1
5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.908
nadE
NAD synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.902
niaX
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.829
CapA
Metallophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.564
rex
Rex family transcripional regulator; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
     
 0.539
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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