Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nadENAD synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (274 aa)    
Predicted Functional Partners:
nadD
Nicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
 
 
 0.994
NadE
Nicotinate phosphoribosyltransferase; Catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.956
ppnK
ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.948
nga
N-acetylglucosamine-1-phosphate uridyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
  0.901
pepC
Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.850
niaX
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.827
NadC
Nicotinate-nucleotide pyrophosphorylase; Catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.801
birA
GntR family transcriptional regulator; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
  
  
 0.766
CinA
Damage-inducible protein CinA; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.730
guaA
GMP synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.727
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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