Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Pbp1APenicillin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (721 aa)    
Predicted Functional Partners:
AKZ49992.1
Penicillin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.996
gpsB
Cell division protein GpsB; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation.
 
 
 
 0.988
recU
Holliday junction resolvase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.959
DacA2
Peptidase M15; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.954
Pbp1b
Transglycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
0.952
Pbp2A
Penicillin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
0.949
DacA1
D-alanyl-D-alanine carboxypeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.930
AKZ49914.1
D-alanyl-D-alanine carboxypeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.907
folP
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
  
  
 0.864
FtsW
Cell division protein FtsW; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SEDS family.
 
 
 
 0.860
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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