STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ligANAD-dependent DNA ligase LigA; This protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; Derived by automated computational analysis using gene prediction method: Protein Homology. (652 aa)    
Predicted Functional Partners:
polC
DNA polymerase III PolC; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
   
  
 0.860
pcrA
ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.803
rsmB
16S rRNA methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
  
  
 0.775
dagK_1
Lipid kinase; Similar to YegS from E. coli; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.772
polA
DNA polymerase I; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.771
LeuS
leucyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.705
ruvB
ATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
  
  
 0.702
topA
DNA topoisomerase I; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.699
DinP
DNA polymerase IV; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.689
addA
ATP-dependent helicase/nuclease subunit A; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.669
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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