Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
thiIThiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (404 aa)    
Predicted Functional Partners:
NifS1
Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.995
NifS2
Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.963
mnmA
Thiouridylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.923
tilS
tRNA(Ile)-lysidine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.902
queA
S-adenosylmethionine tRNA ribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.857
thiT
Thiamine transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.812
thiD
Phosphomethylpyrimidine kinase; Catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.754
CapA
Metallophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.719
tsaB
Peptidase M22; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.706
AKZ50129.1
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.703
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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