Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AKZ50156.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (352 aa)    
Predicted Functional Partners:
apbA
2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
 
   
 0.960
TrxB
ferredoxin-NADP reductase; Catalyzes the oxidation of ferredoxin with NADP; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.707
trmD
tRNA (guanine-N1)-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.617
rimM
16S rRNA processing protein RimM; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.569
FruR
DeoR faimly transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.530
pfkB
Phosphofructokinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.466
FruA
PTS fructose transporter subunit IIC; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.466
Ddh
Lactate dehydrogenase; Catalyzes the formation of pyruvate from lactate; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.456
AKZ49896.1
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.440
AKZ50902.1
Oligohyaluronate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.440
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.