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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AKZ50167.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (126 aa)    
Predicted Functional Partners:
AKZ50168.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.804
AKZ50323.1
Adenylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.618
ezrA
Septation ring formation regulator EzrA; Acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.605
PapS
tRNA CCA-pyrophosphorylase; Catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.558
AKZ50170.1
Antibiotic ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.558
xerS
Site-specific tyrosine recombinase XerS; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.
  
     0.539
AKZ49592.1
Beta-lactamase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.528
AKZ50343.1
Pneumococcal vaccine antigen A; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.508
DivIB
Cell division protein FtsQ; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.494
AKZ51193.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.479
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.