Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
mvaK2Phosphomevalonate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (337 aa)    
Predicted Functional Partners:
mvaK1
Mevalonate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.999
mvaD
Diphosphomevalonate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.999
fni
Isopentenyl pyrophosphate isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
  
 0.996
mvaS
DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.981
mvaA
3-hydroxy-3-methylglutaryl-CoA reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HMG-CoA reductase family.
 
 
 0.931
aphA
Acid phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.817
AKZ49854.1
Beta-lactamase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.447
YvqF
Transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.437
yvqE
Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.437
PheT
phenylalanyl-tRNA synthase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.429
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.