Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
dprADNA protecting protein DprA; Derived by automated computational analysis using gene prediction method: Protein Homology. (278 aa)    
Predicted Functional Partners:
ComEC
Competence protein ComEC; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.969
topA
DNA topoisomerase I; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.967
recA
Recombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.948
ComFA
Competence protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.946
ComFC
Competence protein ComF; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.921
RadC
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.883
ComYA
Competence protein CglA; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.796
CinA
Damage-inducible protein CinA; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.793
rbgA
GTPase; Essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc); Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.789
AKZ50356.1
Ribonuclease HII; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.777
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.