Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DdhLactate dehydrogenase; Catalyzes the formation of pyruvate from lactate; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)    
Predicted Functional Partners:
ldh
Lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.
  
 0.991
pyk
Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.955
AcoB
Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.936
OadA2
Converts oxaloacetate to phosphoenolpyruvate using ATP as an energy source; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.920
AKZ50365.1
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.918
AKZ50367.1
glutaconyl-CoA decarboxylase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.918
AKZ50311.1
Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.915
acoA
Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.912
AKZ50889.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.912
pflB
Formate acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.909
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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