Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
GidtRNA (uracil-5-)-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (448 aa)    
Predicted Functional Partners:
queA
S-adenosylmethionine tRNA ribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.802
topA
DNA topoisomerase I; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.737
SatD
DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.713
SatE
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.713
UppS
UDP pyrophosphate synthase; Catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.616
AKZ50331.1
Glycine/betaine ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.555
Tdk2
Thymidine kinase; Catalyzes the formation of thymidine 5'-phosphate from thymidine; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.528
AKZ50007.1
N-6 DNA methylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
    0.523
frr
Ribosome-recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.
  
    0.510
pyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
  
    0.505
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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