STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ciaHHistidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (436 aa)    
Predicted Functional Partners:
arlR
Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
 0.999
vicR
PhoP family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.958
csrR
PhoB family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.947
Irr
Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.878
SrtR
Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.861
AKZ50802.1
AraC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
     0.851
sptR
Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.845
luxS
S-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) (By similarity); Belongs to the LuxS family.
  
  
 0.682
vicK
Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
0.638
pabB
Aminobenzoate synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.625
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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