STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
udkUridine kinase; Functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)    
Predicted Functional Partners:
upp
Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.
 
 0.998
Cmk
Cytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.985
pyrR
Phosphoribosyl transferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
   
 
 0.946
PyrF
Orotidine 5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.946
pyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
  
 
 0.942
Cdd
Cytidine deaminase; Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.929
udp
Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family.
    
 0.922
AKZ50173.1
5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.909
gap
Glyceraldehyde-3-phosphate dehydrogenase; Also binds human plasminogen.
   
 
 0.862
Snf
RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.855
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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