Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Experiments
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[Homology]
Score
AKZ50649.1Deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (424 aa)    
Predicted Functional Partners:
AKZ49956.1
Esterase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.807
engA
GTP-binding protein Der; EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.780
mlhB
Esterase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.778
nagB
Glucosamine-6-phosphate deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.691
GapN
Glyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.595
MurM
UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.566
agaS
Tagatose-6-phosphate ketose isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.528
hasA
Hyaluronan synthase; Glycosaminoglycan synthesis. The hyaluronic acid capsule is involved in the pathogenicity of group A Streptococci; it may be the major virulence determinant; Belongs to the NodC/HAS family.
 
  
 0.485
PacL
ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.479
Fbp
Dihydroorotate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.431
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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