STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SmeZExosortase; Derived by automated computational analysis using gene prediction method: Protein Homology. (235 aa)    
Predicted Functional Partners:
AKZ49866.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.863
speB
Peptidase C10; Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing. Belongs to the peptidase C10 family.
      
 0.863
slo
Alveolysin; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.826
dnaseB
Mitogenic factor; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.766
AKZ50827.1
DNAse; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.680
nga
N-acetylglucosamine-1-phosphate uridyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.630
cepA
Peptidase S8; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.628
SclA
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.579
scpA-2
Peptidase C5; This virulence factor of S.pyogenes specifically cleaves the human serum chemotaxin C5a at '68-Lys-|-Asp-69' bond near its C- terminus, destroying its ability to serve as a chemoattractant.
      
 0.569
AmrA
Sugar transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.563
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.