STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AKZ50848.1Peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (221 aa)    
Predicted Functional Partners:
AKZ50849.1
Phage portal protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.843
AKZ50952.1
Portal protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.805
clpX
ATP-dependent protease; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
  
 
 0.804
AKZ50847.1
Phage head protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.729
ClpL
Clp protease ClpX; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ClpA/ClpB family.
  
 
 0.685
ClpE
Clp protease ClpX; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.685
ClpC
Clp protease ClpX; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.685
AKZ50850.1
Phage protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.668
AKZ51374.1
Amino acid transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.626
grpE
Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...]
  
 
 0.569
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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