STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AKZ50970.1MutR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa)    
Predicted Functional Partners:
AKZ49845.1
MerR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.794
AKZ51393.1
XRE family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.741
MefE
Macrolide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.470
AKZ50964.1
Serine/threonine protein kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.431
metK2
S-adenosylmethionine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.431
AKZ50966.1
Dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.431
AKZ50967.1
Glutamate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.431
AKZ50968.1
Endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.431
AroE2
Shikimate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.431
speB
Peptidase C10; Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing. Belongs to the peptidase C10 family.
    
 
 0.412
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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