STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
vicRPhoP family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)    
Predicted Functional Partners:
vicK
Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 0.999
vicX
Metallohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.977
ciaH
Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.958
csrS
ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.903
Ihk
Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.896
SptS
Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.840
SrtK
Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.753
pknB
Serine/threonine protein kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
    
 0.634
luxS
S-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) (By similarity); Belongs to the LuxS family.
      
 0.586
PepO
Endopeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.584
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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