Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AKZ51041.1methionyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (78 aa)    
Predicted Functional Partners:
fabG
3-ketoacyl-ACP reductase; Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.966
AKZ51039.1
NAD(P)-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.761
AKZ50075.1
Queuosine transporter QueT; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.627
glmU
Forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.581
AKZ51035.1
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.573
AKZ51036.1
ADP-ribose pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.573
Pfs
5'-methylthioadenosine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
       0.570
AKZ50320.1
Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.507
AKZ49852.1
Sodium:solute symporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.474
AKZ51066.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.445
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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