STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nrdRNrdR family transcriptional regulator; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (164 aa)    
Predicted Functional Partners:
birA
GntR family transcriptional regulator; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
  
  
 0.909
DnaB
Helicase loader; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.872
nrdH
Glutaredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.855
dnaI
Primosomal protein that may act to load helicase DnaC during DNA replication; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.831
argR
Arginine repressor; Regulates arginine biosynthesis genes.
      
 0.777
argR1
ArgR family transcriptional regulator; Regulates arginine biosynthesis genes.
      
 0.770
argR-2
Regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.751
Cmk
Cytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
      0.735
engA
GTP-binding protein Der; EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.663
nrdF-2
Ribonucleoside-diphosphate reductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.646
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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