STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LacFPTS system lactose-specific transporter subunit IIA; Catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; Derived by automated computational analysis using gene prediction method: Protein Homology. (105 aa)    
Predicted Functional Partners:
LacE
PTS system lactose-specific transporter subunits IICB; Phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.999
lacG
6-phospho-beta-galactosidase; Catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.998
LacC2
Tagatose-6-phosphate kinase; Catalyzes the formation of tagatose 1,6-bisphosphate from tagatose 6-phosphate and ATP; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.971
lacD-2
Tagatose-bisphosphate aldolase; Catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.962
ptsH
Phosphocarrier protein HPr; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.941
lacA-2
Galactose-6-phosphate isomerase; Catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; tagatose pathway for galactose utilization; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.941
lacB-2
Galactose-6-phosphate isomerase; Catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.932
licB_1
Cytochrome C biogenesis protein CcmE; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.931
AKZ50543.1
PTS sugar transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.927
LacZ
Beta-galactosidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.908
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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