Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
speBPeptidase C10; Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing. Belongs to the peptidase C10 family. (398 aa)    
Predicted Functional Partners:
scpA-2
Peptidase C5; This virulence factor of S.pyogenes specifically cleaves the human serum chemotaxin C5a at '68-Lys-|-Asp-69' bond near its C- terminus, destroying its ability to serve as a chemoattractant.
   
 
 0.887
cepA
Peptidase S8; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.886
csrS
ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 
 0.865
ska
Kinase; This protein is not a protease, but it activates plasminogen by complexing with it. As a potential virulence factor, it is thought to prevent the formation of effective fibrin barriers around the site of infection, thereby contributing to the invasiveness of the cells (By similarity).
   
  
 0.865
ropB
XRE family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 
 0.864
csrR
PhoB family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.861
SpeG
Exosortase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.860
hasA
Hyaluronan synthase; Glycosaminoglycan synthesis. The hyaluronic acid capsule is involved in the pathogenicity of group A Streptococci; it may be the major virulence determinant; Belongs to the NodC/HAS family.
  
  
 0.860
slo
Alveolysin; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.858
SmeZ
Exosortase; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.858
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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