STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mutSDNA mismatch repair protein MutS; Derived by automated computational analysis using gene prediction method: Protein Homology. (851 aa)    
Predicted Functional Partners:
mutL
DNA mismatch repair protein MutL; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.999
dnaN
DNA polymerase III subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.973
polA
DNA polymerase I; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.966
MutS2
DNA mismatch repair protein MutS; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
0.943
recA
Recombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.709
ruvA
ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
  
  
 0.621
CinA
Damage-inducible protein CinA; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.608
recJ
Single-stranded DNA exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.576
Tag
3-methyladenine DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.568
RadC
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.547
Your Current Organism:
Streptococcus pyogenes
NCBI taxonomy Id: 1314
Other names: ATCC 12344, CCUG 12701, CCUG 4207, CIP 56.41, DSM 20565, JCM 5674, LMG 14700, LMG:14700, Micrococcus scarlatinae, NCAIM B.01705, NCTC 8198, S. pyogenes, Streptococcus erysipelatos, Streptococcus hemolyticus, Streptococcus scarlatinae
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