A0A165WII5 protein (Sistotremastrum suecicum)

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

A0A165WII5

Uncharacterized protein. (632 aa)

Predicted Functional Partners:

A0A166GKS2

0.597

A0A166BQQ0

0.528

A0A165YXI2

0.524

A0A166FEG2

0.524

A0A166C529

0.509

A0A165YKV3

0.505

A0A166FE38

0.505

A0A166G245

0.505

A0A166A3B5

0.504

A0A166B094

0.479

Your Current Organism:

Sistotremastrum suecicum

NCBI taxonomy Id: 1314776
Other names: S. suecicum HHB10207 ss-3, Sistotremastrum suecicum HHB10207 ss-3

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A165WII5	A0A165YKV3	Uncharacterized protein.	Sterol desaturase; Belongs to the sterol desaturase family.	0.505
A0A165WII5	A0A165YXI2	Uncharacterized protein.	Delta-sterol C-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.	0.524
A0A165WII5	A0A166A3B5	Uncharacterized protein.	SE-domain-containing protein.	0.504
A0A165WII5	A0A166B094	Uncharacterized protein.	Sphingosine hydroxylase; Belongs to the sterol desaturase family.	0.479
A0A165WII5	A0A166BQQ0	Uncharacterized protein.	ERG4/ERG24 ergosterol biosynthesis protein.	0.528
A0A165WII5	A0A166C529	Uncharacterized protein.	C-3 sterol dehydrogenase.	0.509
A0A165WII5	A0A166FE38	Uncharacterized protein.	Sterol desaturase; Belongs to the sterol desaturase family.	0.505
A0A165WII5	A0A166FEG2	Uncharacterized protein.	SAM_MT_ERG6_SMT domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.	0.524
A0A165WII5	A0A166G245	Uncharacterized protein.	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	0.505
A0A165WII5	A0A166GKS2	Uncharacterized protein.	Fatty acid hydroxylase; Belongs to the sterol desaturase family.	0.597
A0A165YKV3	A0A165WII5	Sterol desaturase; Belongs to the sterol desaturase family.	Uncharacterized protein.	0.505
A0A165YKV3	A0A165YXI2	Sterol desaturase; Belongs to the sterol desaturase family.	Delta-sterol C-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.	0.832
A0A165YKV3	A0A166A3B5	Sterol desaturase; Belongs to the sterol desaturase family.	SE-domain-containing protein.	0.953
A0A165YKV3	A0A166BQQ0	Sterol desaturase; Belongs to the sterol desaturase family.	ERG4/ERG24 ergosterol biosynthesis protein.	0.889
A0A165YKV3	A0A166C529	Sterol desaturase; Belongs to the sterol desaturase family.	C-3 sterol dehydrogenase.	0.955
A0A165YKV3	A0A166FEG2	Sterol desaturase; Belongs to the sterol desaturase family.	SAM_MT_ERG6_SMT domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.	0.832
A0A165YKV3	A0A166GKS2	Sterol desaturase; Belongs to the sterol desaturase family.	Fatty acid hydroxylase; Belongs to the sterol desaturase family.	0.985
A0A165YXI2	A0A165WII5	Delta-sterol C-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.	Uncharacterized protein.	0.524
A0A165YXI2	A0A165YKV3	Delta-sterol C-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.	Sterol desaturase; Belongs to the sterol desaturase family.	0.832
A0A165YXI2	A0A166A3B5	Delta-sterol C-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.	SE-domain-containing protein.	0.511

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

44

average node degree:

8

avg. local clustering coefficient:

0.907

expected number of edges:

19

PPI enrichment p-value:

3.69e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009099

Valine biosynthetic process

3 of 8

2.03

1.15

0.0062

GO:0009097

Isoleucine biosynthetic process

3 of 14

1.79

1.04

0.0084

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030976

Thiamine pyrophosphate binding

3 of 8

2.03

1.28

0.0034

GO:0004252

Serine-type endopeptidase activity

3 of 25

1.54

0.85

0.0164

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1673

Branched-chain amino acid biosynthetic process, and PEP-utilising enzyme, mobile domain

6 of 20

1.93

3.18

5.40e-08

CL:564

Trypsin-like peptidase domain, and alanyl-tRNA aminoacylation

3 of 6

2.16

1.73

0.00047

CL:1675

Leucine biosynthesis, and Valine biosynthetic process

2 of 8

1.86

0.71

0.0440

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005948

Acetolactate synthase complex

2 of 4

2.16

0.73

0.0439

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0786

Thiamine pyrophosphate

3 of 9

1.98

1.45

0.0014

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13365

Trypsin-like peptidase domain

3 of 3

2.46

1.88

0.00031

PF00205

Thiamine pyrophosphate enzyme, central domain

3 of 4

2.33

1.86

0.00031

PF02776

Thiamine pyrophosphate enzyme, N-terminal TPP binding domain

3 of 5

2.24

1.84

0.00031

PF02775

Thiamine pyrophosphate enzyme, C-terminal TPP binding domain

3 of 6

2.16

1.8

0.00033

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00228

Domain present in PSD-95, Dlg, and ZO-1/2.

2 of 4

2.16

0.95

0.0169

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