A0A166H3N5 protein (Sistotremastrum suecicum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

A0A166H3N5

Uncharacterized protein. (1742 aa)

Predicted Functional Partners:

A0A166EU33

0.930

A0A166EKX7

0.865

A0A166CZ15

0.838

A0A166CXI7

0.778

A0A165WN12

0.772

A0A165ZAL5

0.772

A0A165ZDE7

0.772

A0A166BF51

0.772

A0A166HR84

0.758

A0A166IUE5

0.718

Your Current Organism:

Sistotremastrum suecicum

NCBI taxonomy Id: 1314776
Other names: S. suecicum HHB10207 ss-3, Sistotremastrum suecicum HHB10207 ss-3

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A165WN12	A0A165ZAL5	WD40 repeat-like protein.	WD40 repeat-like protein.	0.735
A0A165WN12	A0A165ZDE7	WD40 repeat-like protein.	WD40 repeat-like protein.	0.771
A0A165WN12	A0A166BF51	WD40 repeat-like protein.	WD_REPEATS_REGION domain-containing protein.	0.765
A0A165WN12	A0A166CXI7	WD40 repeat-like protein.	Ubiquitin-domain-containing protein.	0.649
A0A165WN12	A0A166EU33	WD40 repeat-like protein.	Kinase-like protein; Belongs to the protein kinase superfamily.	0.766
A0A165WN12	A0A166H3N5	WD40 repeat-like protein.	Uncharacterized protein.	0.772
A0A165WN12	A0A166IUE5	WD40 repeat-like protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.469
A0A165ZAL5	A0A165WN12	WD40 repeat-like protein.	WD40 repeat-like protein.	0.735
A0A165ZAL5	A0A165ZDE7	WD40 repeat-like protein.	WD40 repeat-like protein.	0.771
A0A165ZAL5	A0A166BF51	WD40 repeat-like protein.	WD_REPEATS_REGION domain-containing protein.	0.764
A0A165ZAL5	A0A166CXI7	WD40 repeat-like protein.	Ubiquitin-domain-containing protein.	0.649
A0A165ZAL5	A0A166EU33	WD40 repeat-like protein.	Kinase-like protein; Belongs to the protein kinase superfamily.	0.766
A0A165ZAL5	A0A166H3N5	WD40 repeat-like protein.	Uncharacterized protein.	0.772
A0A165ZAL5	A0A166IUE5	WD40 repeat-like protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.469
A0A165ZDE7	A0A165WN12	WD40 repeat-like protein.	WD40 repeat-like protein.	0.771
A0A165ZDE7	A0A165ZAL5	WD40 repeat-like protein.	WD40 repeat-like protein.	0.771
A0A165ZDE7	A0A166BF51	WD40 repeat-like protein.	WD_REPEATS_REGION domain-containing protein.	0.769
A0A165ZDE7	A0A166CXI7	WD40 repeat-like protein.	Ubiquitin-domain-containing protein.	0.649
A0A165ZDE7	A0A166EU33	WD40 repeat-like protein.	Kinase-like protein; Belongs to the protein kinase superfamily.	0.766
A0A165ZDE7	A0A166H3N5	WD40 repeat-like protein.	Uncharacterized protein.	0.772

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

19

average node degree:

3.45

avg. local clustering coefficient:

0.862

expected number of edges:

11

PPI enrichment p-value:

0.0141

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045807

Positive regulation of endocytosis

3 of 53

2.07

0.93

0.0179

GO:0048583

Regulation of response to stimulus

8 of 2903

0.76

0.46

0.0299

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030276

Clathrin binding

3 of 76

1.92

0.92

0.0169

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030136

Clathrin-coated vesicle

3 of 113

1.75

0.82

0.0249

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2776

Mixed, incl. SKAP family, and FYN-binding protein 1/2-like

3 of 6

3.02

2.47

3.25e-05

CL:36429

Membrane attack complex component/perforin/complement C9, and RP1/RP1L1/DCX

2 of 12

2.54

0.96

0.0180

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04144

Endocytosis

5 of 569

1.27

1.12

0.00075

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8856825

Cargo recognition for clathrin-mediated endocytosis

4 of 180

1.67

1.26

0.0021

MAP-8856828

Clathrin-mediated endocytosis

4 of 248

1.53

1.1

0.0036

MAP-196025

Formation of annular gap junctions

2 of 19

2.34

0.88

0.0240

MAP-190873

Gap junction degradation

2 of 21

2.3

0.88

0.0240

MAP-202433

Generation of second messenger molecules

2 of 33

2.1

0.75

0.0406

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005579

Membrane attack complex

3 of 12

2.72

2.31

5.58e-05

GOCC:0098797

Plasma membrane protein complex

4 of 485

1.24

0.66

0.0297

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006020

PTB/PI domain

4 of 56

2.18

2.06

9.63e-05

IPR043443

FYN-binding protein 1/2-like

2 of 3

3.15

1.18

0.0074

IPR029294

Helically-extended SH3 domain

2 of 3

3.15

1.18

0.0074

IPR036028

SH3-like domain superfamily

4 of 258

1.51

0.98

0.0074

IPR001452

SH3 domain

4 of 266

1.5

0.97

0.0074

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00462

Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain

3 of 38

2.22

1.67

0.00067

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