A0A165HYC9 protein (Exidia glandulosa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A165HYC9

Uncharacterized protein. (177 aa)

Predicted Functional Partners:

A0A165NUG4

0.822

cyn1

0.642

A0A166AL68

0.642

A0A165BW57

0.600

A0A165CYK5

0.600

A0A165DDX9

0.600

A0A165QRF9

0.549

A0A165FE36

0.540

A0A165LCN0

0.540

A0A165M6Z3

0.540

Your Current Organism:

Exidia glandulosa

NCBI taxonomy Id: 1314781
Other names: E. glandulosa HHB12029, Exidia glandulosa HHB12029

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A165BW57	A0A165HYC9	A0A165BW57	A0A165HYC9	GH16 domain-containing protein.	Uncharacterized protein.	0.600
A0A165CYK5	A0A165HYC9	A0A165CYK5	A0A165HYC9	ARM repeat-containing protein.	Uncharacterized protein.	0.600
A0A165DDX9	A0A165HYC9	A0A165DDX9	A0A165HYC9	GH16 domain-containing protein.	Uncharacterized protein.	0.600
A0A165FE36	A0A165HYC9	A0A165FE36	A0A165HYC9	Sulfate permease.	Uncharacterized protein.	0.540
A0A165HYC9	A0A165BW57	A0A165HYC9	A0A165BW57	Uncharacterized protein.	GH16 domain-containing protein.	0.600
A0A165HYC9	A0A165CYK5	A0A165HYC9	A0A165CYK5	Uncharacterized protein.	ARM repeat-containing protein.	0.600
A0A165HYC9	A0A165DDX9	A0A165HYC9	A0A165DDX9	Uncharacterized protein.	GH16 domain-containing protein.	0.600
A0A165HYC9	A0A165FE36	A0A165HYC9	A0A165FE36	Uncharacterized protein.	Sulfate permease.	0.540
A0A165HYC9	A0A165LCN0	A0A165HYC9	A0A165LCN0	Uncharacterized protein.	Sulfate permease.	0.540
A0A165HYC9	A0A165M6Z3	A0A165HYC9	A0A165M6Z3	Uncharacterized protein.	Uncharacterized protein.	0.540
A0A165HYC9	A0A165NUG4	A0A165HYC9	A0A165NUG4	Uncharacterized protein.	Uncharacterized protein.	0.822
A0A165HYC9	A0A165QRF9	A0A165HYC9	A0A165QRF9	Uncharacterized protein.	Adenine phosphoribosyltransferase.	0.549
A0A165HYC9	A0A166AL68	A0A165HYC9	A0A166AL68	Uncharacterized protein.	Uncharacterized protein.	0.642
A0A165HYC9	cyn1	A0A165HYC9	A0A165G7R1	Uncharacterized protein.	Cyanate hydratase; Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide; Belongs to the cyanase family.	0.642
A0A165LCN0	A0A165HYC9	A0A165LCN0	A0A165HYC9	Sulfate permease.	Uncharacterized protein.	0.540
A0A165M6Z3	A0A165HYC9	A0A165M6Z3	A0A165HYC9	Uncharacterized protein.	Uncharacterized protein.	0.540
A0A165NUG4	A0A165HYC9	A0A165NUG4	A0A165HYC9	Uncharacterized protein.	Uncharacterized protein.	0.822
A0A165QRF9	A0A165HYC9	A0A165QRF9	A0A165HYC9	Adenine phosphoribosyltransferase.	Uncharacterized protein.	0.549
A0A166AL68	A0A165HYC9	A0A166AL68	A0A165HYC9	Uncharacterized protein.	Uncharacterized protein.	0.642
cyn1	A0A165HYC9	A0A165G7R1	A0A165HYC9	Cyanate hydratase; Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide; Belongs to the cyanase family.	Uncharacterized protein.	0.642

Network Stats

number of nodes:

11

number of edges:

22

average node degree:

4

avg. local clustering coefficient:

0.84

expected number of edges:

11

PPI enrichment p-value:

0.00172

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006631

Fatty acid metabolic process

6 of 221

1.47

1.6

6.34e-05

GO:0140647

P450-containing electron transport chain

2 of 2

3.04

1.32

0.0041

GO:0022900

Electron transport chain

3 of 61

1.73

0.93

0.0137

GO:0006633

Fatty acid biosynthetic process

3 of 70

1.67

0.89

0.0164

GO:0045454

Cell redox homeostasis

2 of 14

2.2

0.85

0.0272

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004165

delta(3)-delta(2)-enoyl-CoA isomerase activity

2 of 4

2.74

1.06

0.0121

GO:0004148

Dihydrolipoyl dehydrogenase activity

2 of 3

2.86

1.06

0.0121

GO:0000062

fatty-acyl-CoA binding

2 of 8

2.44

0.95

0.0181

GO:0016491

Oxidoreductase activity

7 of 1709

0.65

0.38

0.0449

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045252

Oxoglutarate dehydrogenase complex

2 of 7

2.5

1.06

0.0115

GO:0005739

Mitochondrion

8 of 1098

0.9

0.78

0.00052

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10559

Beta-ketoacyl synthase, C-terminal domain, and Lipoate metabolic process

2 of 5

2.64

0.82

0.0329

CL:11194

Mixed, incl. Regulation of intracellular lipid transport, and Protein import into peroxisome matrix

2 of 12

2.26

0.78

0.0365

CL:13747

Mixed, incl. Sulfide oxidation to sulfate, and Sulfate assimilation

2 of 27

1.91

0.76

0.0370

CL:11090

Fatty acid beta-oxidation, and Acyl-CoA dehydrogenase, N-terminal domain

3 of 71

1.67

0.73

0.0365

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

3 of 137

1.38

0.69

0.0328

map00071

Fatty acid degradation

3 of 133

1.39

0.69

0.0328

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2395516

Electron transport from NADPH to Ferredoxin

2 of 3

2.86

1.36

0.0035

MAP-6783984

Glycine degradation

2 of 6

2.56

1.32

0.0039

MAP-389661

Glyoxylate metabolism and glycine degradation

3 of 53

1.79

1.21

0.0035

MAP-1362409

Mitochondrial iron-sulfur cluster biogenesis

2 of 16

2.14

0.97

0.0152

MAP-8978868

Fatty acid metabolism

5 of 345

1.2

0.91

0.0035

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005967

Mitochondrial pyruvate dehydrogenase complex

2 of 5

2.64

1.07

0.0112

GOCC:0005759

Mitochondrial matrix

4 of 165

1.43

0.88

0.0112

GOCC:0005739

Mitochondrion

6 of 857

0.89

0.57

0.0146

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0275

Fatty acid biosynthesis

3 of 9

2.56

2.43

2.99e-05

KW-0520

NAD

2 of 46

1.68

0.71

0.0404

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16113

Enoyl-CoA hydratase/isomerase

3 of 21

2.2

1.54

0.0012

PF02852

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

2 of 4

2.74

1.22

0.0060

PF00070

Pyridine nucleotide-disulphide oxidoreductase

2 of 10

2.34

0.96

0.0175

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001753

Enoyl-CoA hydratase/isomerase

3 of 22

2.18

1.29

0.0037

IPR029045

ClpP/crotonase-like domain superfamily

3 of 34

1.99

1.15

0.0062

IPR016156

FAD/NAD-linked reductase, dimerisation domain superfamily

2 of 5

2.64

1.08

0.0110

IPR004099

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

2 of 4

2.74

1.08

0.0110

IPR001100

Pyridine nucleotide-disulphide oxidoreductase, class I

2 of 4

2.74

1.08

0.0110

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (26%) [HD]

Permalink

Credits

Access

Info

About

STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.

Network

Neighborhood

Databases

Cooccurrence

Textmining

Coexpression

Experiments

Fusion

© STRING Consortium 2024

Credits

Access

Info

About