A0A165JLJ9 protein (Exidia glandulosa) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A165JLJ9

Uncharacterized protein. (220 aa)

Predicted Functional Partners:

A0A165I4E4

0.884

A0A165GIW2

0.814

A0A165GIX3

0.814

A0A165IYY7

0.763

A0A165MPG8

0.760

A0A165HI60

0.697

A0A165EW15

0.679

A0A166MTS8

0.679

A0A165CPC2

0.669

A0A165C6H9

0.665

Your Current Organism:

Exidia glandulosa

NCBI taxonomy Id: 1314781
Other names: E. glandulosa HHB12029, Exidia glandulosa HHB12029

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A165C6H9	A0A165CPC2	Nudix hydrolase domain-containing protein.	S1 motif domain-containing protein.	0.690
A0A165C6H9	A0A165EW15	Nudix hydrolase domain-containing protein.	RNase_PH domain-containing protein.	0.631
A0A165C6H9	A0A165GIW2	Nudix hydrolase domain-containing protein.	XRN1_D1 domain-containing protein.	0.873
A0A165C6H9	A0A165GIX3	Nudix hydrolase domain-containing protein.	Uncharacterized protein.	0.873
A0A165C6H9	A0A165HI60	Nudix hydrolase domain-containing protein.	Uncharacterized protein.	0.683
A0A165C6H9	A0A165I4E4	Nudix hydrolase domain-containing protein.	Uncharacterized protein.	0.638
A0A165C6H9	A0A165JLJ9	Nudix hydrolase domain-containing protein.	Uncharacterized protein.	0.665
A0A165C6H9	A0A165MPG8	Nudix hydrolase domain-containing protein.	Uncharacterized protein.	0.966
A0A165C6H9	A0A166MTS8	Nudix hydrolase domain-containing protein.	RNase_PH domain-containing protein.	0.631
A0A165CPC2	A0A165C6H9	S1 motif domain-containing protein.	Nudix hydrolase domain-containing protein.	0.690
A0A165CPC2	A0A165EW15	S1 motif domain-containing protein.	RNase_PH domain-containing protein.	0.992
A0A165CPC2	A0A165GIW2	S1 motif domain-containing protein.	XRN1_D1 domain-containing protein.	0.793
A0A165CPC2	A0A165GIX3	S1 motif domain-containing protein.	Uncharacterized protein.	0.793
A0A165CPC2	A0A165HI60	S1 motif domain-containing protein.	Uncharacterized protein.	0.999
A0A165CPC2	A0A165I4E4	S1 motif domain-containing protein.	Uncharacterized protein.	0.999
A0A165CPC2	A0A165JLJ9	S1 motif domain-containing protein.	Uncharacterized protein.	0.669
A0A165CPC2	A0A165MPG8	S1 motif domain-containing protein.	Uncharacterized protein.	0.715
A0A165CPC2	A0A166MTS8	S1 motif domain-containing protein.	RNase_PH domain-containing protein.	0.992
A0A165EW15	A0A165C6H9	RNase_PH domain-containing protein.	Nudix hydrolase domain-containing protein.	0.631
A0A165EW15	A0A165CPC2	RNase_PH domain-containing protein.	S1 motif domain-containing protein.	0.992

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

20

average node degree:

3.64

avg. local clustering coefficient:

0.831

expected number of edges:

15

PPI enrichment p-value:

0.12

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006633

Fatty acid biosynthetic process

5 of 44

1.93

2.35

9.39e-06

GO:0044550

Secondary metabolite biosynthetic process

5 of 88

1.63

1.75

7.41e-05

GO:0032787

Monocarboxylic acid metabolic process

6 of 187

1.38

1.47

7.41e-05

GO:0008610

Lipid biosynthetic process

6 of 217

1.31

1.38

8.76e-05

GO:0006629

Lipid metabolic process

7 of 402

1.11

1.12

8.76e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004315

3-oxoacyl-[acyl-carrier-protein] synthase activity

5 of 14

2.43

3.88

2.50e-08

GO:0031177

Phosphopantetheine binding

5 of 20

2.27

3.59

5.69e-08

GO:0043546

Molybdopterin cofactor binding

3 of 3

2.87

2.83

6.50e-06

GO:0030151

Molybdenum ion binding

3 of 8

2.45

2.32

4.28e-05

GO:0016747

Acyltransferase activity, transferring groups other than amino-acyl groups

6 of 123

1.56

2.14

1.41e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8598

Mixed, incl. Phosphopantetheine binding, and Cytochrome P450 - arranged by substrate type

6 of 75

1.78

2.62

4.89e-07

CL:8599

Mixed, incl. Phosphopantetheine binding, and Cytochrome P450 - arranged by substrate type

5 of 67

1.75

2.2

7.20e-06

CL:9180

Molybdenum ion binding, and O2/CO2 exchange in erythrocytes

3 of 14

2.2

1.89

0.00023

CL:8610

Mixed, incl. ACP-like superfamily, and Cytochrome P450 - arranged by substrate type

4 of 50

1.78

1.76

0.00015

CL:8612

ACP-like superfamily, and Cytochrome P450 - arranged by substrate type

3 of 35

1.81

1.33

0.0019

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00920

Sulfur metabolism

2 of 32

1.67

0.69

0.0453

map01110

Biosynthesis of secondary metabolites

6 of 661

0.83

0.59

0.0069

map01100

Metabolic pathways

10 of 2074

0.56

0.44

0.0014

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-163765

ChREBP activates metabolic gene expression

6 of 19

2.37

4.79

1.75e-10

MAP-199220

Vitamin B5 (pantothenate) metabolism

6 of 22

2.31

4.7

1.85e-10

MAP-163685

Integration of energy metabolism

6 of 33

2.13

4.12

1.06e-09

MAP-75105

Fatty acyl-CoA biosynthesis

6 of 42

2.03

3.77

2.99e-09

MAP-8978868

Fatty acid metabolism

7 of 138

1.58

2.55

2.64e-08

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005829

Cytosol

5 of 274

1.13

0.7

0.0163

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0511

Multifunctional enzyme

4 of 10

2.47

3.33

4.12e-07

KW-0596

Phosphopantetheine

4 of 21

2.15

2.76

2.59e-06

KW-0489

Methyltransferase

4 of 97

1.49

1.39

0.00040

KW-0560

Oxidoreductase

5 of 190

1.29

1.26

0.00023

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03404

Mo-co oxidoreductase dimerisation domain

3 of 3

2.87

2.63

1.55e-05

PF00174

Oxidoreductase molybdopterin binding domain

3 of 3

2.87

2.63

1.55e-05

PF00550

Phosphopantetheine attachment site

4 of 17

2.24

2.58

8.93e-06

PF01209

ubiE/COQ5 methyltransferase family

2 of 8

2.27

0.97

0.0158

PF13489

Methyltransferase domain

2 of 13

2.06

0.82

0.0294

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013968

Polyketide synthase, ketoreductase domain

4 of 7

2.63

3.12

1.47e-06

IPR032821

Polyketide synthase, C-terminal extension

4 of 8

2.57

3.1

1.47e-06

IPR013217

Methyltransferase type 12

4 of 8

2.57

3.1

1.47e-06

IPR042104

Polyketide synthase, dehydratase domain superfamily

4 of 9

2.52

3.08

1.47e-06

IPR020807

Polyketide synthase, dehydratase domain

4 of 9

2.52

3.08

1.47e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00829

Enoylreductase

4 of 5

2.78

3.84

7.00e-08

SM00826

PKS_DH

4 of 6

2.7

3.81

7.00e-08

SM00822

This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.

4 of 6

2.7

3.81

7.00e-08

SM00827

Acyl transferase domain in polyketide synthase (PKS) enzymes.

4 of 10

2.47

3.56

1.39e-07

SM00825

Beta-ketoacyl synthase

3 of 5

2.65

2.79

6.39e-06

(more ...)

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