A0A166MCF2 protein (Exidia glandulosa) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A166MCF2

Uncharacterized protein. (88 aa)

Predicted Functional Partners:

A0A165Q6B4

0.993

A0A165C165

0.974

A0A165Q135

0.947

A0A165QKE3

0.943

A0A165M6Y3

0.928

A0A165DWT5

0.909

A0A165ENY5

0.909

A0A165MB72

0.905

A0A165MQM9

0.886

A0A166AAC9

0.886

Your Current Organism:

Exidia glandulosa

NCBI taxonomy Id: 1314781
Other names: E. glandulosa HHB12029, Exidia glandulosa HHB12029

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A165C165	A0A165DWT5	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	Glutamate-tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.988
A0A165C165	A0A165ENY5	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	Glutamate-tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.988
A0A165C165	A0A165M6Y3	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	Nucleic acid-binding protein.	0.990
A0A165C165	A0A165MB72	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.954
A0A165C165	A0A165MQM9	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	Isoleucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.760
A0A165C165	A0A165Q135	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	Methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.995
A0A165C165	A0A165Q6B4	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	Tyrosine--tRNA ligase.	0.993
A0A165C165	A0A165QKE3	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	Glutamine-tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.992
A0A165C165	A0A166AAC9	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetase.	0.760
A0A165C165	A0A166MCF2	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	Uncharacterized protein.	0.974
A0A165DWT5	A0A165C165	Glutamate-tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.988
A0A165DWT5	A0A165M6Y3	Glutamate-tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family.	Nucleic acid-binding protein.	0.996
A0A165DWT5	A0A165MB72	Glutamate-tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.641
A0A165DWT5	A0A165MQM9	Glutamate-tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family.	Isoleucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.881
A0A165DWT5	A0A165Q135	Glutamate-tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family.	Methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.983
A0A165DWT5	A0A165Q6B4	Glutamate-tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family.	Tyrosine--tRNA ligase.	0.992
A0A165DWT5	A0A165QKE3	Glutamate-tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family.	Glutamine-tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.981
A0A165DWT5	A0A166AAC9	Glutamate-tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family.	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetase.	0.881
A0A165DWT5	A0A166MCF2	Glutamate-tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family.	Uncharacterized protein.	0.909
A0A165ENY5	A0A165C165	Glutamate-tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.988

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Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.841

expected number of edges:

13

PPI enrichment p-value:

0.00128

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006172

ADP biosynthetic process

2 of 2

3.04

1.56

0.0015

GO:0009179

Purine ribonucleoside diphosphate metabolic process

3 of 19

2.24

1.51

0.0014

GO:0009167

Purine ribonucleoside monophosphate metabolic process

3 of 20

2.22

1.51

0.0014

GO:0032386

Regulation of intracellular transport

3 of 25

2.12

1.49

0.0014

GO:0003400

Regulation of COPII vesicle coating

2 of 4

2.74

1.44

0.0024

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050145

Nucleoside monophosphate kinase activity

3 of 6

2.74

2.27

6.86e-05

GO:0004017

Adenylate kinase activity

2 of 3

2.87

1.41

0.0028

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6770

Multivesicular body sorting pathway, and Calpain-like thiol protease family.

6 of 31

2.33

4.58

4.21e-10

CL:6820

Calpain-like thiol protease family., and Regulation of COPII vesicle coating

4 of 6

2.87

3.97

4.53e-08

CL:12808

Metabolism of nucleotides, and Biosynthesis of maresins

3 of 56

1.77

1.05

0.0078

CL:6793

Multivesicular body sorting pathway

2 of 10

2.35

0.95

0.0176

CL:12890

Deoxyribonucleotide biosynthetic process, and Nucleoside monophosphate kinase activity

2 of 15

2.17

0.87

0.0245

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04626

Plant-pathogen interaction

2 of 5

2.65

1.62

0.0011

map00230

Purine metabolism

4 of 100

1.65

1.6

0.00023

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-499943

Interconversion of nucleotide di- and triphosphates

3 of 25

2.12

1.46

0.0016

MAP-15869

Metabolism of nucleotides

3 of 68

1.69

0.92

0.0140

MAP-9668328

Sealing of the nuclear envelope (NE) by ESCRT-III

2 of 13

2.23

0.88

0.0239

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042584

Chromaffin granule membrane

2 of 3

2.87

1.19

0.0071

GOCC:0005935

Cellular bud neck

2 of 18

2.09

0.85

0.0258

GOCC:0043227

Membrane-bounded organelle

9 of 3197

0.49

0.33

0.0258

GOCC:0043229

Intracellular organelle

10 of 4076

0.43

0.3

0.0258

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13207

AAA domain

2 of 2

3.04

1.31

0.0044

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036193

Adenylate kinase, active site lid domain superfamily

2 of 2

3.04

1.06

0.0125

IPR007862

Adenylate kinase, active site lid domain

2 of 2

3.04

1.06

0.0125

IPR006259

Adenylate kinase subfamily

2 of 2

3.04

1.06

0.0125

IPR033690

Adenylate kinase, conserved site

2 of 3

2.87

1.05

0.0125

IPR000850

Adenylate kinase/UMP-CMP kinase

2 of 3

2.87

1.05

0.0125

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00054

EF-hand, calcium binding motif

2 of 15

2.17

0.81

0.0317

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