STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DW2_15825Hypothetical protein. (476 aa)    
Predicted Functional Partners:
parE
DNA topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily.
    
 
 0.751
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
    
 
 0.751
DW2_15555
PAS/PAC sensor hybrid histidine kinase; COG2202 FOG: PAS/PAC domain.
  
 0.725
DW2_09909
Signal transduction histidine kinase; COG2202 FOG: PAS/PAC domain.
    
 0.674
DW2_15820
Putative type I secretion system ATPase.
       0.526
DW2_05045
COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family.
    
  0.524
DW2_06888
Glycosyl transferase family protein; COG0457 FOG: TPR repeat.
  
  
 0.491
DW2_15815
COG4618 ABC-type protease/lipase transport system, ATPase and permease components.
       0.438
DW2_15810
COG0845 Membrane-fusion protein.
       0.432
DW2_14395
COG5002 Signal transduction histidine kinase.
    
 0.419
Your Current Organism:
Thioclava atlantica
NCBI taxonomy Id: 1317124
Other names: LMG 27145, LMG:27145, MCCC 1A02612, T. atlantica, Thioclava atlantica Lai et al. 2015, Thioclava sp. 13D2W-2, strain 13D2W-2
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