node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GAM12767.1 | GAM16587.1 | SAMD00020551_0902 | SAMD00020551_4816 | Uncharacterized SAV1743 homolog; Belongs to the UPF0354 family. | YjbH-like, GTP pyrophosphokinase domain. | 0.699 |
GAM12767.1 | mecA | SAMD00020551_0902 | SAMD00020551_4811 | Uncharacterized SAV1743 homolog; Belongs to the UPF0354 family. | Negative regulator of genetic competence MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.622 |
GAM13271.1 | GAM16403.1 | SAMD00020551_1409 | SAMD00020551_4593 | Hypothetical protein SA_21. | DNA replication intiation control protein YabA; Involved in initiation control of chromosome replication. Belongs to the YabA family. | 0.591 |
GAM13271.1 | mecA | SAMD00020551_1409 | SAMD00020551_4811 | Hypothetical protein SA_21. | Negative regulator of genetic competence MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.590 |
GAM13488.1 | GAM13489.1 | SAMD00020551_1633 | SAMD00020551_1634 | Acetyltransferase, GNAT family. | Hypothetical protein. | 0.773 |
GAM13488.1 | mecA | SAMD00020551_1633 | SAMD00020551_4811 | Acetyltransferase, GNAT family. | Negative regulator of genetic competence MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.766 |
GAM13489.1 | GAM13488.1 | SAMD00020551_1634 | SAMD00020551_1633 | Hypothetical protein. | Acetyltransferase, GNAT family. | 0.773 |
GAM13489.1 | mecA | SAMD00020551_1634 | SAMD00020551_4811 | Hypothetical protein. | Negative regulator of genetic competence MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.766 |
GAM13756.1 | mecA | SAMD00020551_1902 | SAMD00020551_4811 | ClpB protein; Belongs to the ClpA/ClpB family. | Negative regulator of genetic competence MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.857 |
GAM14843.1 | mecA | SAMD00020551_2997 | SAMD00020551_4811 | ATP-dependent Clp protease, ATP-binding subunit ClpC/negative regulator of genetic competence clcC/mecB; Belongs to the ClpA/ClpB family. | Negative regulator of genetic competence MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.948 |
GAM15956.1 | mecA | SAMD00020551_4127 | SAMD00020551_4811 | Thioredoxin; Belongs to the thioredoxin family. | Negative regulator of genetic competence MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.594 |
GAM16403.1 | GAM13271.1 | SAMD00020551_4593 | SAMD00020551_1409 | DNA replication intiation control protein YabA; Involved in initiation control of chromosome replication. Belongs to the YabA family. | Hypothetical protein SA_21. | 0.591 |
GAM16403.1 | mecA | SAMD00020551_4593 | SAMD00020551_4811 | DNA replication intiation control protein YabA; Involved in initiation control of chromosome replication. Belongs to the YabA family. | Negative regulator of genetic competence MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.693 |
GAM16587.1 | GAM12767.1 | SAMD00020551_4816 | SAMD00020551_0902 | YjbH-like, GTP pyrophosphokinase domain. | Uncharacterized SAV1743 homolog; Belongs to the UPF0354 family. | 0.699 |
GAM16587.1 | mecA | SAMD00020551_4816 | SAMD00020551_4811 | YjbH-like, GTP pyrophosphokinase domain. | Negative regulator of genetic competence MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.636 |
clpB | mecA | SAMD00020551_3866 | SAMD00020551_4811 | ClpB protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Negative regulator of genetic competence MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.857 |
mecA | GAM12767.1 | SAMD00020551_4811 | SAMD00020551_0902 | Negative regulator of genetic competence MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | Uncharacterized SAV1743 homolog; Belongs to the UPF0354 family. | 0.622 |
mecA | GAM13271.1 | SAMD00020551_4811 | SAMD00020551_1409 | Negative regulator of genetic competence MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | Hypothetical protein SA_21. | 0.590 |
mecA | GAM13488.1 | SAMD00020551_4811 | SAMD00020551_1633 | Negative regulator of genetic competence MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | Acetyltransferase, GNAT family. | 0.766 |
mecA | GAM13489.1 | SAMD00020551_4811 | SAMD00020551_1634 | Negative regulator of genetic competence MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | Hypothetical protein. | 0.766 |