STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
T1I159_RHOPRRibonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (307 aa)    
Predicted Functional Partners:
T1HQT3_RHOPR
Uncharacterized protein.
   
 
 0.997
R4G4N7_RHOPR
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 
 0.980
R4FM65_RHOPR
Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
   
 
 0.963
T1IAU5_RHOPR
DNA primase; Belongs to the eukaryotic-type primase small subunit family.
  
  
 0.955
T1HUW2_RHOPR
DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.
   
 
 0.951
T1I0G8_RHOPR
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
    
 
 0.946
R4FLX4_RHOPR
Putative ribonuclease h1/h2 small subunit.
   
 
 0.944
T1HES0_RHOPR
Thymidylat_synt domain-containing protein.
  
 
 0.936
MCM7
DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]
   
  
 0.908
R4G8J7_RHOPR
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.
   
 
 0.900
Your Current Organism:
Rhodnius prolixus
NCBI taxonomy Id: 13249
Other names: R. prolixus
Server load: low (14%) [HD]