node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Fen1 | R4FMR4_RHOPR | T1I6X2 | R4FMR4 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Putative polynucleotide kinase 3' phosphatase. | 0.448 |
Fen1 | R4G4E3_RHOPR | T1I6X2 | R4G4E3 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.569 |
Fen1 | R4G4N7_RHOPR | T1I6X2 | R4G4N7 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.999 |
Fen1 | R4G8A3_RHOPR | T1I6X2 | R4G8A3 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family. | 0.992 |
Fen1 | T1HAP8_RHOPR | T1I6X2 | T1HAP8 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | BRCT domain-containing protein. | 0.758 |
Fen1 | T1HAP9_RHOPR | T1I6X2 | T1HAP9 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | XRCC1_N domain-containing protein. | 0.758 |
Fen1 | T1I325_RHOPR | T1I6X2 | T1I325 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Ku domain-containing protein. | 0.733 |
Fen1 | T1I3M7_RHOPR | T1I6X2 | T1I3M7 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | PARP-type domain-containing protein. | 0.839 |
Fen1 | T1I7Y7_RHOPR | T1I6X2 | T1I7Y7 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Ku domain-containing protein. | 0.569 |
R4FMR4_RHOPR | Fen1 | R4FMR4 | T1I6X2 | Putative polynucleotide kinase 3' phosphatase. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.448 |
R4FMR4_RHOPR | R4G4E3_RHOPR | R4FMR4 | R4G4E3 | Putative polynucleotide kinase 3' phosphatase. | Uncharacterized protein. | 0.505 |
R4FMR4_RHOPR | R4G8A3_RHOPR | R4FMR4 | R4G8A3 | Putative polynucleotide kinase 3' phosphatase. | DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family. | 0.698 |
R4FMR4_RHOPR | T1HAP8_RHOPR | R4FMR4 | T1HAP8 | Putative polynucleotide kinase 3' phosphatase. | BRCT domain-containing protein. | 0.960 |
R4FMR4_RHOPR | T1HAP9_RHOPR | R4FMR4 | T1HAP9 | Putative polynucleotide kinase 3' phosphatase. | XRCC1_N domain-containing protein. | 0.960 |
R4FMR4_RHOPR | T1I325_RHOPR | R4FMR4 | T1I325 | Putative polynucleotide kinase 3' phosphatase. | Ku domain-containing protein. | 0.653 |
R4FMR4_RHOPR | T1I3M7_RHOPR | R4FMR4 | T1I3M7 | Putative polynucleotide kinase 3' phosphatase. | PARP-type domain-containing protein. | 0.841 |
R4FMR4_RHOPR | T1I7Y7_RHOPR | R4FMR4 | T1I7Y7 | Putative polynucleotide kinase 3' phosphatase. | Ku domain-containing protein. | 0.505 |
R4G4E3_RHOPR | Fen1 | R4G4E3 | T1I6X2 | Uncharacterized protein. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.569 |
R4G4E3_RHOPR | R4FMR4_RHOPR | R4G4E3 | R4FMR4 | Uncharacterized protein. | Putative polynucleotide kinase 3' phosphatase. | 0.505 |
R4G4E3_RHOPR | R4G4N7_RHOPR | R4G4E3 | R4G4N7 | Uncharacterized protein. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.496 |