STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemBPorphobilinogen synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ALAD family. (323 aa)    
Predicted Functional Partners:
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
 0.998
hemD
Porphyrin biosynthesis protein HemD.
 
 
 0.996
hemL
Glutamate-1-semialdehyde aminotransferase (aminomutase); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 
 0.994
hemA
Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.920
ribF
Riboflavin biosynthesis protein RibF; Belongs to the ribF family.
     
 0.848
hpt
Hypoxanthine phosphoribosyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
    0.821
tilS
tRNA(Ile)-lysidine synthase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family.
       0.820
NSJP_3575
Homologs of previously reported genes of unknown function.
       0.819
NSJP_0809
Putative Uroporphyrinogen III synthase HemD (modular protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
  
 
 0.771
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 
 0.658
Your Current Organism:
Nitrospira japonica
NCBI taxonomy Id: 1325564
Other names: N. japonica, Nitrospira sp. NJ1
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