Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
thiItRNA 4-thiouridine(8) synthase ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (404 aa)    
Predicted Functional Partners:
OLF50358.1
Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.957
OLF50735.1
Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.739
mnmA
Hypothetical protein; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
 
  
 0.681
OLF50310.1
16S rRNA (cytosine(967)-C(5))-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
    0.631
trmB
tRNA (guanosine(46)-N7)-methyltransferase TrmB; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
   
  
 0.591
OLF50381.1
Ribosome maturation factor RimM; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.582
OLF49579.1
tRNA lysidine(34) synthetase TilS; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.582
OLF50305.1
Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.574
queA
tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
  
  
 0.538
OLF50357.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.519
Your Current Organism:
Streptococcus acidominimus
NCBI taxonomy Id: 1326
Other names: ATCC 51725, CCUG 27296, CIP 82.4, DSM 20622, LMG 17755, LMG:17755, NCDO 2025, NCIMB 702025, NCTC 12957, S. acidominimus
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