A0A164ZUV7 protein (Xylona heveae) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

A0A164ZUV7

Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (716 aa)

Predicted Functional Partners:

A0A165JWJ5

0.908

A0A165I1M3

0.900

A0A164ZAW6

0.861

A0A165HKY3

0.854

A0A165JU35

0.854

A0A165GKY0

0.852

A0A165FLC2

0.836

A0A165GLT0

0.836

A0A165ILB0

0.836

A0A165J600

0.823

Your Current Organism:

Xylona heveae

NCBI taxonomy Id: 1328760
Other names: X. heveae TC161, Xylona heveae TC161

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A164ZAW6	A0A164ZUV7	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	0.861
A0A164ZAW6	A0A165I1M3	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	Nicotinate phosphoribosyltransferas-like protein.	0.934
A0A164ZAW6	A0A165J600	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	Uncharacterized protein.	0.801
A0A164ZAW6	A0A165JWJ5	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	Nicotinamide-nucleotide adenylyltransferase; Belongs to the eukaryotic NMN adenylyltransferase family.	0.901
A0A164ZUV7	A0A164ZAW6	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	0.861
A0A164ZUV7	A0A165FLC2	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	DHS-like NAD/FAD-binding domain-containing protein.	0.836
A0A164ZUV7	A0A165GKY0	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	SIR2-domain-containing protein.	0.852
A0A164ZUV7	A0A165GLT0	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily.	0.836
A0A164ZUV7	A0A165HKY3	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	ATP-NAD kinase.	0.854
A0A164ZUV7	A0A165I1M3	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	Nicotinate phosphoribosyltransferas-like protein.	0.900
A0A164ZUV7	A0A165ILB0	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	DHS-like NAD/FAD-binding domain-containing protein.	0.836
A0A164ZUV7	A0A165J600	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	Uncharacterized protein.	0.823
A0A164ZUV7	A0A165JU35	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	Putative NAD+ kinase.	0.854
A0A164ZUV7	A0A165JWJ5	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	Nicotinamide-nucleotide adenylyltransferase; Belongs to the eukaryotic NMN adenylyltransferase family.	0.908
A0A165FLC2	A0A164ZUV7	DHS-like NAD/FAD-binding domain-containing protein.	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	0.836
A0A165FLC2	A0A165GKY0	DHS-like NAD/FAD-binding domain-containing protein.	SIR2-domain-containing protein.	0.819
A0A165FLC2	A0A165GLT0	DHS-like NAD/FAD-binding domain-containing protein.	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily.	0.920
A0A165FLC2	A0A165HKY3	DHS-like NAD/FAD-binding domain-containing protein.	ATP-NAD kinase.	0.810
A0A165FLC2	A0A165I1M3	DHS-like NAD/FAD-binding domain-containing protein.	Nicotinate phosphoribosyltransferas-like protein.	0.642
A0A165FLC2	A0A165ILB0	DHS-like NAD/FAD-binding domain-containing protein.	DHS-like NAD/FAD-binding domain-containing protein.	0.844

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Network Stats

number of nodes:

11

number of edges:

30

average node degree:

5.45

avg. local clustering coefficient:

0.848

expected number of edges:

11

PPI enrichment p-value:

7.77e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045116

Protein neddylation

4 of 6

3.02

4.15

2.39e-08

GO:0032446

Protein modification by small protein conjugation

8 of 195

1.81

3.61

2.01e-10

GO:0019941

Modification-dependent protein catabolic process

5 of 249

1.5

0.00018

GO:0016567

Protein ubiquitination

4 of 176

1.55

1.3

0.0011

GO:0006511

Ubiquitin-dependent protein catabolic process

4 of 241

1.41

1.04

0.0036

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031625

Ubiquitin protein ligase binding

4 of 31

2.3

2.63

8.04e-06

GO:0019788

NEDD8 transferase activity

2 of 2

3.19

1.6

0.0013

GO:0019787

Ubiquitin-like protein transferase activity

3 of 145

1.51

0.72

0.0334

GO:0005515

Protein binding

5 of 886

0.94

0.52

0.0376

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031463

Cul3-RING ubiquitin ligase complex

3 of 3

3.19

3.02

3.32e-06

GO:0031461

cullin-RING ubiquitin ligase complex

4 of 54

2.06

2.35

1.62e-05

GO:0019005

SCF ubiquitin ligase complex

2 of 22

2.15

0.98

0.0147

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2918

Protein neddylation, and SCF ubiquitin ligase complex

7 of 19

2.76

7.48

3.06e-15

CL:2914

cullin-RING ubiquitin ligase complex, and COP9 signalosome

8 of 42

2.47

7.15

1.16e-15

CL:2941

Protein neddylation

3 of 5

2.97

2.93

4.46e-06

CL:2920

Mixed, incl. Nuclear SCF ubiquitin ligase complex, and Cullin

2 of 10

2.49

1.13

0.0086

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04120

Ubiquitin mediated proteolysis

7 of 131

1.92

4.01

9.32e-11

map04141

Protein processing in endoplasmic reticulum

3 of 221

1.32

0.71

0.0259

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8951664

Neddylation

6 of 131

1.85

2.96

1.00e-07

MAP-9013422

RHOBTB1 GTPase cycle

2 of 20

2.19

0.91

0.0206

MAP-9013418

RHOBTB2 GTPase cycle

2 of 24

2.11

0.9

0.0206

MAP-597592

Post-translational protein modification

6 of 798

1.07

0.86

0.0019

MAP-9706574

RHOBTB GTPase Cycle

2 of 32

1.99

0.82

0.0285

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031463

Cul3-RING ubiquitin ligase complex

3 of 3

3.19

3.14

1.99e-06

GOCC:0031461

cullin-RING ubiquitin ligase complex

5 of 65

2.08

3.02

4.52e-07

GOCC:1902494

Catalytic complex

7 of 954

1.06

1.03

0.00012

GOCC:0019005

SCF ubiquitin ligase complex

2 of 37

1.93

0.71

0.0463

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045093

Cullin

3 of 4

3.07

2.57

2.20e-05

IPR001373

Cullin, N-terminal

3 of 5

2.97

2.56

2.20e-05

IPR016159

Cullin repeat-like-containing domain superfamily

3 of 6

2.89

2.55

2.20e-05

IPR019559

Cullin protein, neddylation domain

2 of 3

3.02

1.4

0.0030

IPR036317

Cullin homology domain superfamily

2 of 4

2.89

1.35

0.0036

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00884

Cullin protein neddylation domain

2 of 3

3.02

1.6

0.0013

SM00182

Cullin

2 of 3

3.02

1.6

0.0013

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