A0A165FM18 protein (Xylona heveae) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

A0A165FM18

VHS domain-containing protein. (411 aa)

Predicted Functional Partners:

A0A164ZWN4

0.864

A0A165IRE7

0.687

A0A165IDH2

0.593

A0A165FHK7

0.589

A0A165GB47

0.589

A0A164ZCS6

0.575

A0A161TFU7

0.567

A0A165GXA1

0.562

A0A165HHJ0

0.552

A0A165GB57

0.549

Your Current Organism:

Xylona heveae

NCBI taxonomy Id: 1328760
Other names: X. heveae TC161, Xylona heveae TC161

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A161TFU7	A0A165FM18	Natural resistance-associated macrophage protein.	VHS domain-containing protein.	0.567
A0A164ZCS6	A0A164ZWN4	SH3-domain-containing protein.	ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	0.715
A0A164ZCS6	A0A165FM18	SH3-domain-containing protein.	VHS domain-containing protein.	0.575
A0A164ZCS6	A0A165GB47	SH3-domain-containing protein.	Ras-domain-containing protein.	0.682
A0A164ZCS6	A0A165GXA1	SH3-domain-containing protein.	ARF/SAR protein; Belongs to the small GTPase superfamily. Arf family.	0.543
A0A164ZCS6	A0A165IDH2	SH3-domain-containing protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.720
A0A164ZWN4	A0A164ZCS6	ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	SH3-domain-containing protein.	0.715
A0A164ZWN4	A0A165FM18	ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	VHS domain-containing protein.	0.864
A0A164ZWN4	A0A165GB47	ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	Ras-domain-containing protein.	0.680
A0A164ZWN4	A0A165HHJ0	ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	Vacuolar sorting receptor.	0.615
A0A164ZWN4	A0A165IDH2	ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.759
A0A165FHK7	A0A165FM18	DUF500-domain-containing protein.	VHS domain-containing protein.	0.589
A0A165FM18	A0A161TFU7	VHS domain-containing protein.	Natural resistance-associated macrophage protein.	0.567
A0A165FM18	A0A164ZCS6	VHS domain-containing protein.	SH3-domain-containing protein.	0.575
A0A165FM18	A0A164ZWN4	VHS domain-containing protein.	ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	0.864
A0A165FM18	A0A165FHK7	VHS domain-containing protein.	DUF500-domain-containing protein.	0.589
A0A165FM18	A0A165GB47	VHS domain-containing protein.	Ras-domain-containing protein.	0.589
A0A165FM18	A0A165GB57	VHS domain-containing protein.	Glycoside hydrolase family 2 protein.	0.549
A0A165FM18	A0A165GXA1	VHS domain-containing protein.	ARF/SAR protein; Belongs to the small GTPase superfamily. Arf family.	0.562
A0A165FM18	A0A165HHJ0	VHS domain-containing protein.	Vacuolar sorting receptor.	0.552

page 1 of 3

Network Stats

number of nodes:

8

number of edges:

14

average node degree:

3.5

avg. local clustering coefficient:

0.917

expected number of edges:

7

PPI enrichment p-value:

0.0143

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007166

Cell surface receptor signaling pathway

7 of 693

1.29

1.44

3.00e-05

GO:0007165

Signal transduction

8 of 1955

0.9

0.74

0.0011

GO:0050896

Response to stimulus

9 of 3344

0.72

0.56

0.0020

GO:0050794

Regulation of cellular process

10 of 5149

0.58

0.43

0.0042

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030246

Carbohydrate binding

7 of 132

2.01

4.1

2.68e-10

GO:0004930

G protein-coupled receptor activity

7 of 507

1.43

1.94

8.88e-07

GO:0004888

Transmembrane signaling receptor activity

8 of 782

1.3

1.73

4.94e-07

GO:0005488

Binding

11 of 9143

0.37

0.27

0.0289

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

10 of 2717

0.85

1.09e-05

GO:0016021

Integral component of membrane

9 of 3482

0.7

0.56

0.0011

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:16238

Mixed, incl. GPCR, family 2, secretin-like, and UPA domain

8 of 17

2.96

9.93

9.99e-20

CL:16217

Leucine-rich repeat, typical subtype, and GPCR, family 2, secretin-like

10 of 73

2.43

8.9

1.47e-20

CL:16241

Mixed, incl. GAIN domain, N-terminal, and Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

6 of 12

2.99

7.35

1.63e-14

CL:16243

Mixed, incl. Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, and Carboxypeptidase-like, regulatory domain superfamily

3 of 6

2.99

3.12

1.99e-06

CL:16297

Leucine-rich repeats, typical (most populated) subfamily, and Positive regulation of p38MAPK cascade

2 of 31

2.1

0.84

0.0274

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-373080

Class B/2 (Secretin family receptors)

3 of 23

2.4

1.85

0.00034

MAP-500792

GPCR ligand binding

4 of 218

1.55

1.19

0.0023

MAP-6798695

Neutrophil degranulation

4 of 344

1.35

0.91

0.0074

MAP-372790

Signaling by GPCR

4 of 374

1.32

0.89

0.0074

MAP-168249

Innate Immune System

5 of 721

1.13

0.78

0.0074

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030054

Cell junction

5 of 354

1.44

1.29

0.00062

GOCC:0071944

Cell periphery

6 of 1234

0.98

0.71

0.0050

GOCC:0016020

Membrane

8 of 2681

0.76

0.57

0.0040

GOCC:0005886

Plasma membrane

5 of 1118

0.94

0.51

0.0393

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0675

Receptor

3 of 345

1.23

0.61

0.0422

KW-1133

Transmembrane helix

10 of 4462

0.64

0.53

0.00037

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00002

7 transmembrane receptor (Secretin family)

8 of 50

2.49

7.39

4.17e-16

PF16489

GPCR-Autoproteolysis INducing (GAIN) domain

2 of 4

2.99

1.43

0.0026

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000832

GPCR, family 2, secretin-like

8 of 50

2.49

7.2

1.20e-15

IPR017981

GPCR, family 2-like, transmembrane domain

8 of 52

2.48

7.16

1.20e-15

IPR046338

GAIN domain superfamily

3 of 21

2.44

1.9

0.00028

IPR032471

GAIN domain, N-terminal

2 of 4

2.99

1.35

0.0037

IPR001879

GPCR, family 2, extracellular hormone receptor domain

2 of 17

2.36

0.8

0.0338

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00303

G-protein-coupled receptor proteolytic site domain

2 of 17

2.36

0.89

0.0235

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