A0A165GCL9 protein (Xylona heveae) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

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A0A165GCL9

COX assembly mitochondrial protein; Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration; Belongs to the CMC family. (150 aa)

Predicted Functional Partners:

A0A164Z8W0

0.576

A0A165HMD1

0.549

A0A165FTM7

0.526

A0A165GDS8

0.525

A0A165HE52

0.517

A0A165AKT4

0.461

A0A165GH63

0.446

A0A165H6B0

0.446

A0A165FZD9

0.434

A0A165GCN3

0.434

Your Current Organism:

Xylona heveae

NCBI taxonomy Id: 1328760
Other names: X. heveae TC161, Xylona heveae TC161

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A164Z8W0	A0A165GCL9	Uncharacterized protein.	COX assembly mitochondrial protein; Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration; Belongs to the CMC family.	0.576
A0A164Z8W0	A0A165HE52	Uncharacterized protein.	Uncharacterized protein.	0.704
A0A164Z8W0	A0A165HMD1	Uncharacterized protein.	Cytochrome c oxidase copper chaperone protein.	0.591
A0A165AKT4	A0A165GCL9	ARM repeat-containing protein.	COX assembly mitochondrial protein; Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration; Belongs to the CMC family.	0.461
A0A165AKT4	A0A165HMD1	ARM repeat-containing protein.	Cytochrome c oxidase copper chaperone protein.	0.696
A0A165FTM7	A0A165FZD9	ARM repeat-containing protein.	Mitochondrial inner membrane protease ATP23; Has a dual role in the assembly of mitochondrial ATPase. Belongs to the peptidase M76 family.	0.416
A0A165FTM7	A0A165GCL9	ARM repeat-containing protein.	COX assembly mitochondrial protein; Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration; Belongs to the CMC family.	0.526
A0A165FTM7	A0A165GDS8	ARM repeat-containing protein.	Putative mitochondrial intermembrane space translocase subunit Tim10.	0.526
A0A165FTM7	A0A165H6B0	ARM repeat-containing protein.	Uncharacterized protein.	0.416
A0A165FTM7	A0A165HE52	ARM repeat-containing protein.	Uncharacterized protein.	0.416
A0A165FTM7	A0A165HMD1	ARM repeat-containing protein.	Cytochrome c oxidase copper chaperone protein.	0.851
A0A165FZD9	A0A165FTM7	Mitochondrial inner membrane protease ATP23; Has a dual role in the assembly of mitochondrial ATPase. Belongs to the peptidase M76 family.	ARM repeat-containing protein.	0.416
A0A165FZD9	A0A165GCL9	Mitochondrial inner membrane protease ATP23; Has a dual role in the assembly of mitochondrial ATPase. Belongs to the peptidase M76 family.	COX assembly mitochondrial protein; Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration; Belongs to the CMC family.	0.434
A0A165FZD9	A0A165GDS8	Mitochondrial inner membrane protease ATP23; Has a dual role in the assembly of mitochondrial ATPase. Belongs to the peptidase M76 family.	Putative mitochondrial intermembrane space translocase subunit Tim10.	0.546
A0A165FZD9	A0A165HE52	Mitochondrial inner membrane protease ATP23; Has a dual role in the assembly of mitochondrial ATPase. Belongs to the peptidase M76 family.	Uncharacterized protein.	0.681
A0A165GCL9	A0A164Z8W0	COX assembly mitochondrial protein; Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration; Belongs to the CMC family.	Uncharacterized protein.	0.576
A0A165GCL9	A0A165AKT4	COX assembly mitochondrial protein; Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration; Belongs to the CMC family.	ARM repeat-containing protein.	0.461
A0A165GCL9	A0A165FTM7	COX assembly mitochondrial protein; Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration; Belongs to the CMC family.	ARM repeat-containing protein.	0.526
A0A165GCL9	A0A165FZD9	COX assembly mitochondrial protein; Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration; Belongs to the CMC family.	Mitochondrial inner membrane protease ATP23; Has a dual role in the assembly of mitochondrial ATPase. Belongs to the peptidase M76 family.	0.434
A0A165GCL9	A0A165GCN3	COX assembly mitochondrial protein; Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration; Belongs to the CMC family.	tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.	0.434

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Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.949

expected number of edges:

23

PPI enrichment p-value:

5.57e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042274

Ribosomal small subunit biogenesis

6 of 59

1.95

3.11

9.96e-08

GO:0042254

Ribosome biogenesis

8 of 250

1.45

2.15

9.96e-08

GO:0000462

Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

3 of 27

1.99

1.41

0.0017

GO:0006364

rRNA processing

5 of 187

1.37

1.22

0.00075

GO:0006412

Translation

5 of 264

1.22

0.97

0.0022

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

5 of 143

1.49

1.37

0.00047

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022627

Cytosolic small ribosomal subunit

4 of 19

2.27

2.68

5.69e-06

GO:0030688

Preribosome, small subunit precursor

3 of 10

2.42

2.29

4.86e-05

GO:0030684

Preribosome

4 of 78

1.65

1.7

0.00012

GO:0005840

Ribosome

5 of 151

1.47

1.61

5.22e-05

GO:1990904

Ribonucleoprotein complex

7 of 382

1.21

1.35

1.65e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4381

Cytosolic small ribosomal subunit, and GTP hydrolysis and joining of the 60S ribosomal subunit

5 of 20

2.34

3.67

5.20e-08

CL:5063

Preribosome, small subunit precursor, and RIO kinase

4 of 10

2.55

3.25

6.82e-07

CL:5066

Preribosome, small subunit precursor, and rRNA-binding

3 of 5

2.72

2.77

7.73e-06

CL:4383

Cytosolic small ribosomal subunit, and Ribosomal protein L2, domain 2

3 of 13

2.31

2.2

6.15e-05

CL:4397

Mixed, incl. Ribosomal protein S8, and Ribosomal protein S5/S7

2 of 6

2.47

1.41

0.0025

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

5 of 167

1.42

1.49

0.00010

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6791226

Major pathway of rRNA processing in the nucleolus and cytosol

9 of 124

1.81

4.19

6.50e-13

MAP-8868773

rRNA processing in the nucleus and cytosol

9 of 128

1.79

4.14

6.50e-13

MAP-72312

rRNA processing

9 of 132

1.78

4.08

6.50e-13

MAP-72695

Formation of the ternary complex, and subsequently, the 43S complex

5 of 59

1.87

2.67

8.88e-07

MAP-72702

Ribosomal scanning and start codon recognition

5 of 65

1.83

2.57

1.17e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0022627

Cytosolic small ribosomal subunit

5 of 26

2.23

3.45

9.71e-08

GOCC:0030688

Preribosome, small subunit precursor

3 of 13

2.31

2.15

7.73e-05

GOCC:1990904

Ribonucleoprotein complex

8 of 374

1.28

1.7

3.59e-07

GOCC:0032991

Protein-containing complex

9 of 1912

0.62

0.48

0.0017

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

5 of 49

1.95

2.87

4.66e-07

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