LRRK2 protein (Pteropus vampyrus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LRRK2

Leucine rich repeat kinase 2. (2520 aa)

Predicted Functional Partners:

YWHAQ

0.883

RAB29

0.828

MSN

0.803

CDC37

0.790

TSC1

0.781

ENSPVAP00000002817

0.768

HSP90AB1

0.768

HSP90AA1

0.768

TRAF7

0.752

MAPT

0.750

Your Current Organism:

Pteropus vampyrus

NCBI taxonomy Id: 132908
Other names: P. vampyrus, large flying fox

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC37	ENSPVAP00000002817	ENSPVAP00000003491	ENSPVAP00000002817	Cell division cycle 37.	annotation not available	0.967
CDC37	HSP90AA1	ENSPVAP00000003491	ENSPVAP00000016778	Cell division cycle 37.	Heat shock protein 90 alpha family class A member 1.	0.967
CDC37	HSP90AB1	ENSPVAP00000003491	ENSPVAP00000015876	Cell division cycle 37.	Heat shock protein 90 alpha family class B member 1.	0.967
CDC37	LRRK2	ENSPVAP00000003491	ENSPVAP00000001023	Cell division cycle 37.	Leucine rich repeat kinase 2.	0.790
CDC37	TSC1	ENSPVAP00000003491	ENSPVAP00000001944	Cell division cycle 37.	TSC complex subunit 1.	0.844
ENSPVAP00000002817	CDC37	ENSPVAP00000002817	ENSPVAP00000003491	annotation not available	Cell division cycle 37.	0.967
ENSPVAP00000002817	HSP90AA1	ENSPVAP00000002817	ENSPVAP00000016778	annotation not available	Heat shock protein 90 alpha family class A member 1.	0.688
ENSPVAP00000002817	LRRK2	ENSPVAP00000002817	ENSPVAP00000001023	annotation not available	Leucine rich repeat kinase 2.	0.768
ENSPVAP00000002817	MAPT	ENSPVAP00000002817	ENSPVAP00000007399	annotation not available	Microtubule associated protein tau.	0.629
ENSPVAP00000002817	YWHAQ	ENSPVAP00000002817	ENSPVAP00000005049	annotation not available	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta.	0.613
HSP90AA1	CDC37	ENSPVAP00000016778	ENSPVAP00000003491	Heat shock protein 90 alpha family class A member 1.	Cell division cycle 37.	0.967
HSP90AA1	ENSPVAP00000002817	ENSPVAP00000016778	ENSPVAP00000002817	Heat shock protein 90 alpha family class A member 1.	annotation not available	0.688
HSP90AA1	HSP90AB1	ENSPVAP00000016778	ENSPVAP00000015876	Heat shock protein 90 alpha family class A member 1.	Heat shock protein 90 alpha family class B member 1.	0.677
HSP90AA1	LRRK2	ENSPVAP00000016778	ENSPVAP00000001023	Heat shock protein 90 alpha family class A member 1.	Leucine rich repeat kinase 2.	0.768
HSP90AA1	MAPT	ENSPVAP00000016778	ENSPVAP00000007399	Heat shock protein 90 alpha family class A member 1.	Microtubule associated protein tau.	0.629
HSP90AA1	YWHAQ	ENSPVAP00000016778	ENSPVAP00000005049	Heat shock protein 90 alpha family class A member 1.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta.	0.613
HSP90AB1	CDC37	ENSPVAP00000015876	ENSPVAP00000003491	Heat shock protein 90 alpha family class B member 1.	Cell division cycle 37.	0.967
HSP90AB1	HSP90AA1	ENSPVAP00000015876	ENSPVAP00000016778	Heat shock protein 90 alpha family class B member 1.	Heat shock protein 90 alpha family class A member 1.	0.677
HSP90AB1	LRRK2	ENSPVAP00000015876	ENSPVAP00000001023	Heat shock protein 90 alpha family class B member 1.	Leucine rich repeat kinase 2.	0.768
HSP90AB1	MAPT	ENSPVAP00000015876	ENSPVAP00000007399	Heat shock protein 90 alpha family class B member 1.	Microtubule associated protein tau.	0.629