STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TOP1DNA topoisomerase I. (833 aa)    
Predicted Functional Partners:
TDP1
tyrosyl-DNA phosphodiesterase 1.
    
 
 0.966
TOP2B
DNA topoisomerase II beta.
   
 
 0.939
TOP2A
DNA topoisomerase II alpha.
   
 
 0.937
RNASEH2A
Ribonuclease H2 subunit A.
   
 
 0.927
PARP1
poly(ADP-ribose) polymerase 1.
    
 
 0.881
SUMO1
Small ubiquitin like modifier 1.
   
 0.824
RECQL4
RecQ like helicase 4.
  
 
 0.821
BLM
BLM RecQ like helicase.
   
 
 0.820
UBE2I
Ubiquitin conjugating enzyme E2 I.
    
 0.806
KCTD2
Potassium channel tetramerization domain containing 2.
    
 0.806
Your Current Organism:
Pteropus vampyrus
NCBI taxonomy Id: 132908
Other names: P. vampyrus, large flying fox
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.