ENSPVAP00000005189 protein (Pteropus vampyrus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSPVAP00000005189

annotation not available (341 aa)

Predicted Functional Partners:

PPP6C

0.995

PPP2CB

0.986

PPP4C

0.986

PPP2CA

0.986

MTOR

0.964

TIPRL

0.957

RPTOR

0.953

MLST8

0.946

AKT1S1

0.897

DEPTOR

0.876

Your Current Organism:

Pteropus vampyrus

NCBI taxonomy Id: 132908
Other names: P. vampyrus, large flying fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1S1	DEPTOR	ENSPVAP00000010353	ENSPVAP00000003515	AKT1 substrate 1.	DEP domain containing MTOR interacting protein.	0.945
AKT1S1	ENSPVAP00000005189	ENSPVAP00000010353	ENSPVAP00000005189	AKT1 substrate 1.	annotation not available	0.897
AKT1S1	MLST8	ENSPVAP00000010353	ENSPVAP00000004819	AKT1 substrate 1.	MTOR associated protein, LST8 homolog.	0.996
AKT1S1	MTOR	ENSPVAP00000010353	ENSPVAP00000013937	AKT1 substrate 1.	Mechanistic target of rapamycin kinase.	0.997
AKT1S1	RPTOR	ENSPVAP00000010353	ENSPVAP00000008016	AKT1 substrate 1.	Regulatory associated protein of MTOR complex 1.	0.999
DEPTOR	AKT1S1	ENSPVAP00000003515	ENSPVAP00000010353	DEP domain containing MTOR interacting protein.	AKT1 substrate 1.	0.945
DEPTOR	ENSPVAP00000005189	ENSPVAP00000003515	ENSPVAP00000005189	DEP domain containing MTOR interacting protein.	annotation not available	0.876
DEPTOR	MLST8	ENSPVAP00000003515	ENSPVAP00000004819	DEP domain containing MTOR interacting protein.	MTOR associated protein, LST8 homolog.	0.998
DEPTOR	MTOR	ENSPVAP00000003515	ENSPVAP00000013937	DEP domain containing MTOR interacting protein.	Mechanistic target of rapamycin kinase.	0.996
DEPTOR	RPTOR	ENSPVAP00000003515	ENSPVAP00000008016	DEP domain containing MTOR interacting protein.	Regulatory associated protein of MTOR complex 1.	0.998
ENSPVAP00000005189	AKT1S1	ENSPVAP00000005189	ENSPVAP00000010353	annotation not available	AKT1 substrate 1.	0.897
ENSPVAP00000005189	DEPTOR	ENSPVAP00000005189	ENSPVAP00000003515	annotation not available	DEP domain containing MTOR interacting protein.	0.876
ENSPVAP00000005189	MLST8	ENSPVAP00000005189	ENSPVAP00000004819	annotation not available	MTOR associated protein, LST8 homolog.	0.946
ENSPVAP00000005189	MTOR	ENSPVAP00000005189	ENSPVAP00000013937	annotation not available	Mechanistic target of rapamycin kinase.	0.964
ENSPVAP00000005189	PPP2CA	ENSPVAP00000005189	ENSPVAP00000011717	annotation not available	Protein phosphatase 2 catalytic subunit alpha.	0.986
ENSPVAP00000005189	PPP2CB	ENSPVAP00000005189	ENSPVAP00000002052	annotation not available	Protein phosphatase 2 catalytic subunit beta.	0.986
ENSPVAP00000005189	PPP4C	ENSPVAP00000005189	ENSPVAP00000009945	annotation not available	Protein phosphatase 4 catalytic subunit.	0.986
ENSPVAP00000005189	PPP6C	ENSPVAP00000005189	ENSPVAP00000007647	annotation not available	Protein phosphatase 6 catalytic subunit.	0.995
ENSPVAP00000005189	RPTOR	ENSPVAP00000005189	ENSPVAP00000008016	annotation not available	Regulatory associated protein of MTOR complex 1.	0.953
ENSPVAP00000005189	TIPRL	ENSPVAP00000005189	ENSPVAP00000004798	annotation not available	TOR signaling pathway regulator.	0.957

page 1 of 4

Network Stats

number of nodes:

9

number of edges:

15

average node degree:

3.33

avg. local clustering coefficient:

0.917

expected number of edges:

16

PPI enrichment p-value:

0.675

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006479

Protein methylation

6 of 57

1.9

2.91

2.29e-07

GO:0016571

Histone methylation

4 of 25

2.08

2.31

2.22e-05

GO:0006325

Chromatin organization

7 of 177

1.48

2.04

8.15e-07

GO:0051568

Histone H3-K4 methylation

3 of 11

2.31

1.91

0.00024

GO:0016570

Histone modification

5 of 88

1.63

1.88

2.97e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030527

Structural constituent of chromatin

3 of 9

2.4

1.75

0.00055

GO:0046982

Protein heterodimerization activity

3 of 29

1.89

1.13

0.0061

GO:0042800

Histone methyltransferase activity (H3-K4 specific)

2 of 5

2.48

0.98

0.0162

GO:0005515

Protein binding

6 of 689

0.82

0.48

0.0311

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035097

Histone methyltransferase complex

4 of 9

2.53

3.22

7.64e-07

GO:0048188

Set1C/COMPASS complex

3 of 8

2.45

2.34

3.90e-05

GO:0000786

Nucleosome

3 of 11

2.31

2.18

6.80e-05

GO:0005694

Chromosome

8 of 326

1.27

1.64

7.64e-07

GO:0070210

Rpd3L-Expanded complex

2 of 3

2.7

1.62

0.0011

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:34202282

(2021) Using Genealogical Concordance and Coalescent-Based Species Delimitation to Assess Species Boundaries in the Diaporthe eres Complex.

2 of 2

2.88

1.82

0.00049

PMID:25264384

(2014) Species limits in Diaporthe: molecular re-assessment of D. citri, D. cytosporella, D. foeniculina and D. rudis.

2 of 2

2.88

1.82

0.00049

PMID:34456375

(2020) Mating genes in Calonectria and evidence for a heterothallic ancestral state.

2 of 3

2.7

1.81

0.00049

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2696

Histone methyltransferase complex, and Structural constituent of chromatin

8 of 25

2.38

6.92

1.24e-15

CL:2689

PKMTs methylate histone lysines, and Structural constituent of chromatin

9 of 37

2.26

6.86

1.78e-16

CL:2475

Mixed, incl. Histone modification, and Chromatin remodeling

10 of 171

1.65

3.75

3.88e-14

CL:2726

Set1C/COMPASS complex, and Histone H3

4 of 10

2.48

3.49

1.97e-07

CL:2699

Mixed, incl. Nucleosome core, and Regulation of PTEN gene transcription

4 of 13

2.37

3.26

4.33e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00310

Lysine degradation

3 of 82

1.44

0.76

0.0240

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3214841

PKMTs methylate histone lysines

5 of 29

2.11

3.1

3.48e-07

MAP-4839726

Chromatin organization

6 of 81

1.75

2.62

3.48e-07

MAP-3247509

Chromatin modifying enzymes

6 of 81

1.75

2.62

3.48e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000786

Nucleosome

3 of 12

2.28

1.66

0.00072

GOCC:0035097

Histone methyltransferase complex

3 of 14

2.21

1.65

0.00072

GOCC:0070210

Rpd3L-Expanded complex

2 of 5

2.48

1.31

0.0039

GOCC:0000785

Chromatin

5 of 145

1.42

1.26

0.00072

GOCC:0048188

Set1C/COMPASS complex

2 of 7

2.33

1.2

0.0060

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0158

Chromosome

3 of 10

2.36

2.07

0.00012

KW-0544

Nucleosome core

2 of 5

2.48

1.4

0.0026

KW-0539

Nucleus

6 of 309

1.17

1.16

0.00013

KW-0853

WD repeat

3 of 99

1.36

0.79

0.0164

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR007125

Histone H2A/H2B/H3

3 of 6

2.58

1.85

0.00038

IPR000164

Histone H3/CENP-A

2 of 2

2.88

1.15

0.0083

IPR009072

Histone-fold

3 of 25

1.96

1.11

0.0073

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00428

Histone H3

2 of 3

2.7

1.27

0.0049

SM00317

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

2 of 14

2.03

0.82

0.0292

SM00320

WD40 repeats

3 of 113

1.3

0.63

0.0415

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