STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APH1BAph-1 homolog B, gamma-secretase subunit. (255 aa)    
Predicted Functional Partners:
NCSTN
Nicastrin.
   
 0.997
PSEN1
Presenilin 1.
   
 0.995
PSEN2
Presenilin 2.
   
 0.994
NOTCH1
Notch receptor 1.
    
 0.938
NOTCH3
Notch receptor 3.
    
 0.900
NOTCH2
Notch receptor 2.
    
 0.895
NOTCH4
Notch receptor 4.
    
 0.895
APH1A
Aph-1 homolog A, gamma-secretase subunit.
  
  
 
0.876
APP
Amyloid beta precursor protein.
    
 0.805
BACE2
Beta-secretase 2.
      
 0.771
Your Current Organism:
Pteropus vampyrus
NCBI taxonomy Id: 132908
Other names: P. vampyrus, large flying fox
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.