STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A4X06_g281Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1710 aa)    
Predicted Functional Partners:
A4X06_g1341
DNA_mis_repair domain-containing protein.
   
 0.947
A4X06_g5502
Uncharacterized protein.
   
 0.896
A4X06_g4198
ERCC4 domain-containing protein.
    
 0.811
A4X06_g3707
DRMBL domain-containing protein.
    
 0.798
SLX1
Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
   
 
 0.784
A4X06_g7862
Uncharacterized protein.
    
 0.771
A4X06_g2164
Uncharacterized protein.
     
 0.771
A4X06_g2604
ERCC4 domain-containing protein.
    
 0.771
A4X06_g883
POLAc domain-containing protein.
   
 
 0.768
A4X06_g476
MutL_C domain-containing protein.
   
 0.752
Your Current Organism:
Tilletia controversa
NCBI taxonomy Id: 13291
Other names: T. controversa, Tilletia contraversa, dwarf bunt fungus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.