node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KKC25091.1 | KKC25093.1 | WP12_15780 | WP12_15790 | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Ribonucleotide-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | 0.999 |
KKC25091.1 | dut | WP12_15780 | WP12_19515 | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.915 |
KKC25091.1 | ndk | WP12_15780 | WP12_18845 | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Phosphodiesterase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.942 |
KKC25091.1 | thyA | WP12_15780 | WP12_09510 | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.903 |
KKC25091.1 | tmk | WP12_15780 | WP12_03090 | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.929 |
KKC25093.1 | KKC25091.1 | WP12_15790 | WP12_15780 | Ribonucleotide-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.999 |
KKC25093.1 | dut | WP12_15790 | WP12_19515 | Ribonucleotide-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.437 |
KKC25093.1 | ndk | WP12_15790 | WP12_18845 | Ribonucleotide-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | Phosphodiesterase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.941 |
KKC25093.1 | tmk | WP12_15790 | WP12_03090 | Ribonucleotide-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.914 |
KKC27486.1 | KKC27488.1 | WP12_03085 | WP12_03095 | Peptidase S11; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S11 family. | DNA polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.887 |
KKC27486.1 | KKC27494.1 | WP12_03085 | WP12_03075 | Peptidase S11; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S11 family. | Lytic transglycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.913 |
KKC27486.1 | tmk | WP12_03085 | WP12_03090 | Peptidase S11; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S11 family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.884 |
KKC27488.1 | KKC27486.1 | WP12_03095 | WP12_03085 | DNA polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Peptidase S11; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S11 family. | 0.887 |
KKC27488.1 | KKC27494.1 | WP12_03095 | WP12_03075 | DNA polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Lytic transglycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.884 |
KKC27488.1 | tmk | WP12_03095 | WP12_03090 | DNA polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.898 |
KKC27494.1 | KKC27486.1 | WP12_03075 | WP12_03085 | Lytic transglycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Peptidase S11; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S11 family. | 0.913 |
KKC27494.1 | KKC27488.1 | WP12_03075 | WP12_03095 | Lytic transglycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | DNA polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.884 |
KKC27494.1 | tmk | WP12_03075 | WP12_03090 | Lytic transglycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.884 |
coaX | tmk | WP12_19235 | WP12_03090 | Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.890 |
dut | KKC25091.1 | WP12_19515 | WP12_15780 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.915 |