STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
W1Q0Z1_AMBTCDUF1681 domain-containing protein. (284 aa)    
Predicted Functional Partners:
W1PYR5_AMBTC
AP-2 complex subunit alpha; Subunit of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome.
    
 0.945
W1PQ28_AMBTC
MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.
    
 0.932
U5DH00_AMBTC
Rhodanese domain-containing protein.
    
 0.898
W1PE37_AMBTC
Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.
     
 0.882
W1NSC6_AMBTC
Beta-adaptin-like protein; Subunit of clathrin-associated adaptor protein complex that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
    
 0.857
W1NY12_AMBTC
Beta-adaptin-like protein; Subunit of clathrin-associated adaptor protein complex that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
    
 0.857
W1NW27_AMBTC
AP-1 complex subunit gamma.
    
 0.848
U5DCC1_AMBTC
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
    
  0.803
W1PPS7_AMBTC
MHD domain-containing protein.
    
 0.802
U5D420_AMBTC
Uncharacterized protein.
    
 0.749
Your Current Organism:
Amborella trichopoda
NCBI taxonomy Id: 13333
Other names: A. trichopoda, Amborella trichopoda Baill.
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.